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Keynote Speaker

Assist. Prof. Alessandra Zanut

Department of Chemical Sciences - DiSC, University of Padua, Italy

E-mail

alessandra.zanut@unipd.it

Advanced Nanofabrication Strategies for Electrochemical/ECL sensing Platforms and Functional Biointerfaces

Nanofabrication represents not merely a means of reducing feature size, but a powerful strategy for the precise engineering of analytical and biological interfaces, with direct implications for both sensing performance and the development of physiologically relevant model systems. In this framework, thermal nanoimprint lithography, electron-beam lithography, and thermal scanning probe lithography are employed for the fabrication of nanoelectrode arrays, multiplexed electrochemiluminescence (ECL) platforms, and large-area tissue-mimetic replicas with sub-15 nm resolution. Such nanoscale control enables the rational design of functional interfaces exhibiting ultrasensitive electrochemical response, geometry-dependent modulation of ECL emission, and high-resolution ECL imaging capabilities [1]. In parallel, complementary bio-nanofabrication approaches afford reusable quasi-three-dimensional replicas and UV-tunable ultrathin polymeric films with bone-mimetic stiffness, providing effective platforms for the modulation of stem cell adhesion and differentiation [2-3]. Collectively, these nanofabrication strategies establish a versatile technological framework for the realization of advanced sensing platforms and functional biointerfaces, while offering new opportunities for the in vitro reproduction of physiologically relevant microenvironments.

References:

[1] C. Mariani, A. Fracassa, P. Pastore, S. Bogialli, F. Paolucci, G. Valenti, A. Zanut*, Chemical & Biomedical Imaging 2025 3 (7), 462-469, DOI: 10.1021/cbmi.5c00022

[2] X. Liu, A. Zanut (first co-author), M. Sladkova-Faure, L. Xiea, M. Weck, X. Zheng, E. Riedo, G. M. de Peppo, Adv. Func. Mat. 2021, 31, 20088662. https://doi.org/10.1002/adfm.202008662. Cover Article.

[3] A. Zanut, R. Li, R. Deng, X. Liu, M. Rejhon, W. Chen, M. Weck, G. M. de Peppo*, E. Riedo*, Advance Healthcare Materials 2022. https://doi.org/10.1002/adhm.202201503

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